Juglone
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra)... more
Product information "Juglone"
Description: Juglone (Regianin) is a natural naphthoquinone found in the black walnut (J. nigra) and other plants in the Juglandaceae family. Juglone also irreversibly inhibits peptidyl-prolyl cis/trans isomerases of the parvulin family, including human Pin1, yeast Ess1/Ptf1, and E. coli parvulin (Ki = 55.9 nM). Juglone also blocks transcription by RNA polymerases I, II, and III (IC50s = 2-7 µM) and attenuates kidney fibrosis in rats treated with unilateral ureteral obstruction, both through Pin1-independent mechanisms. Target: Antibacterial, DNA/RNA Synthesis. Smiles: Oc1cccc2C(=O)C=CC(=O)c12. References: Hennig L, et al. Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone. Biochemistry. 1998 Apr 28,37(17):5953-60.
| Keywords: | 5-Hydroxy-1,4-naphthoquinone, Regianin |
| Supplier: | TargetMol |
| Supplier-Nr: | T4010 |
Properties
| Application: | Irreversible Pin1 inhibitor |
| MW: | 174.15 D |
| Formula: | C10H6O3 |
Database Information
| CAS : | 481-39-0| Matching products |
| KEGG ID : | K09578 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301, H315, H319, H335, H400 |
| P Phrases: | P261, P264, P270, P271, P273, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P391, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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