JQKD82 (hydrochloride)

JQKD82 is a prodrug form of KDM5-C49, an inhibitor of Jumonji AT-rich interactive domain 1A (JARID1A), also known as lysine-specific demethylase 5A (KDM5A). It increases the levels of trimethylated lysine 4 on histone 3 (H3K4me3) in MOLP-8 and MM.1S multiple myeloma cells when used at concentrations of 0.3 and 1 µM. JQKD82 reduces the proliferation of MOLP-8 and MM.1S cells in a concentration-dependent manner and decreases the viability of primary CD138+ cells from patients with multiple myeloma when used at a concentration of 3 µM. It induces cell cycle arrest at the G0/G1 phase, as well as induces apoptosis, in MOLP-8 and MM.1S cells when used at a concentration of 1 µM. JQKD82 (50 mg/kg twice per day) decreases tumor growth and increases survival in a MOLP-8 mouse xenograft model.Formal Name: 2-[[[2-[[2-(dimethylamino)ethyl]ethylamino]-2-oxoethyl]amino]methyl]-4-pyridinecarboxylic acid, 2,4-bis(1-methylethoxy)phenyl ester, trihydrochloride. CAS Number: 2863676-87-1. Synonyms: JADA82, PCK82. Molecular Formula: C27H40N4O5 . 3HCl. Formula Weight: 610.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingy soluble: 1-10 mg/ml, PBS (pH 7.2): Soluble: >10 mg/ml. SMILES: O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OC2=CC=C(OC(C)C)C=C2OC(C)C.Cl.Cl.Cl. InChi Code: InChI=1S/C27H40N4O5.3ClH/c1-8-31(14-13-30(6)7)26(32)18-28-17-22-15-21(11-12-29-22)27(33)36-24-10-9-23(34-19(2)3)16-25(24)35-20(4)5,,,/h9-12,15-16,19-20,28H,8,13-14,17-18H2,1-7H3,3*1H. InChi Key: VSTHCFWHQMJPDZ-UHFFFAOYSA-N.