JNJ-63533054

JNJ-63533054 is a potent agonist of the orphan G protein-coupled receptor GPR139 (EC50 = 16 nM in HEK293 cells expressing human GPR139). It is selective for GPR139 over 50 known G protein-coupled receptors, ion channels, and transporters as determined by an external selectivity panel. Tritium-labeled JNJ-63533054 has been used in displacement assays to identify physiological ligands of GPR139.Formal Name: 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]-benzamide. CAS Number: 1802326-66-4. Molecular Formula: C17H17ClN2O2. Formula Weight: 316.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 5 mg/ml. SMILES: ClC1=CC=CC(C(NCC(N[C@@H](C)C2=CC=CC=C2)=O)=O)=C1. InChi Code: InChI=1S/C17H17ClN2O2/c1-12(13-6-3-2-4-7-13)20-16(21)11-19-17(22)14-8-5-9-15(18)10-14/h2-10,12H,11H2,1H3,(H,19,22)(H,20,21)/t12-/m0/s1. InChi Key: MWDVCHRYCKXEBY-LBPRGKRZSA-N.