JNJ-26481585 (hydrochloride)

JNJ-26481585 is a histone deacetylase (HDAC) inhibitor. It inhibits class I (IC50s = 0.11, 0.33, 4.86, and 4.26 nM for HDAC1, -2, -3, and -8, respectively), class IIa (IC50s = 0.64, 3.69, 119, and 32.1 nM for HDAC4, -5, 7-, and -9, respectively), and class IIb HDACs (IC50s = 76.8 and 0.46 nM for HDAC6 and HDAC10, respectively), as well as HDAC11 (IC50 = 0.37 nM), the class IV HDAC. JNJ-26481585 (200 nM) induces apoptosis, pyroptosis, and ferroptosis in CAL-27 and Tca8113 tongue squamous cell carcinoma cells. It also induces histone H3 acetylation in tumor tissue in vivo and completely inhibits tumor growth in HCT116 Ras mutant and C170HM2 mouse xenograft models when administered at a dose of 10 mg/kg once per day.Formal Name: N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide, dihydrochloride. CAS Number: 875320-31-3. Synonyms: Quisinostat. Molecular Formula: C21H26N6O2 . 2HCl. Formula Weight: 467.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml, DMSO: 20 mg/ml, Ethanol: 1.5 mg/ml. lambdamax: 217, 276 nm. SMILES: CN(C1=C2C=CC=C1)C=C2CNCC3CCN(C4=NC=C(C(NO)=O)C=N4)CC3.Cl.Cl. InChi Code: InChI=1S/C21H26N6O2.2ClH/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29,,/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28),2*1H. InChi Key: NRUIZESXVMJDKR-UHFFFAOYSA-N.