JNJ-0966

JNJ-0966 is an inhibitor of matrix metalloproteinase-9 (MMP-9) zymogen activation (IC50 = 440 nM). It is selective for MMP-9 over MMP-1, MMP-2, and MMP-3 zymogen activation at 10 µM and does not inhibit the catalytic activity of MMP-1, -2, -3, -9, or -14. It inhibits invasion of HT-1080 cells in a MatrigelTM assay (IC50 = 1 µM). JNJ-0966 (10 and 30 mg/kg, twice per day) reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).Formal Name: N-[2-[(2-methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]-acetamide. CAS Number: 315705-75-0. Molecular Formula: C16H16N4O2S2. Formula Weight: 360.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Methanol: soluble. lambdamax: 261, 311 nm. SMILES: COC1=C(C=CC=C1)NC2=NC(C3=C(C)N=C(NC(C)=O)S3)=CS2. InChi Code: InChI=1S/C16H16N4O2S2/c1-9-14(24-16(17-9)18-10(2)21)12-8-23-15(20-12)19-11-6-4-5-7-13(11)22-3/h4-8H,1-3H3,(H,19,20)(H,17,18,21). InChi Key: ZADCDCMLLGDCRM-UHFFFAOYSA-N.