JGB1741

Item number	Size	Manual	Delivery time	Price
TGM-T22094-1mg	1 mg	-	7 - 10 business days*	53.00€
TGM-T22094-5mg	5 mg	-	7 - 10 business days*	174.00€
TGM-T22094-1mL	1 ml	-	7 - 10 business days*	208.00€
TGM-T22094-10mg	10 mg	-	7 - 10 business days*	290.00€
TGM-T22094-25mg	25 mg	-	7 - 10 business days*	512.00€
TGM-T22094-50mg	50 mg	-	7 - 10 business days*	744.00€
TGM-T22094-100mg	100 mg	-	7 - 10 business days*	1,039.00€

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Description: JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of... more

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Product information "JGB1741"

Description: JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 µM. It modulates the Bax/Bcl2 ratio, cytochrome c release, and PARP cleavage, and increases acetylated p53 levels, leading to p53-mediated apoptosis. JGB1741 can be used in breast cancer studies. Target: Sirtuin. Smiles: Oc1ccc2ccccc2c1\C=N\c1sc2CCCCc2c1C(=O)NCc1ccccc1. References: Arunasree M Kalle, et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8,401(1):13-9.

Keywords:	ILS-JGB-1741
Supplier:	TargetMol
Supplier-Nr:	T22094

Properties

Application:	SIRT1 inhibitor
MW:	440.56 D
Formula:	C27H24N2O2S

Database Information

CAS :	1256375-38-8\| Matching products
KEGG ID :	K11411 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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