Jervine
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Larger quantity required? Request bulk
Description: The biological activity of Jervine (Jerwiny) is mediated via its interaction with... more
Product information "Jervine"
Description: The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed. Target: Smo, Hedgehog/Smoothened. Smiles: [H][C@@]12NC[C@@H](C)C[C@H]1O[C@]1(CC[C@]3([H])C(C(=O)[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)[C@@H]2C. References: ten Berge D, et al. Development. 2001, 128(15):2929-38.
| Keywords: | 11-Ketocyclopamine, Iervin, Jerwiny |
| Supplier: | TargetMol |
| Supplier-Nr: | T3363 |
Properties
| Application: | Sonic hedgehog pathway inhibitor, birth defect inducer |
| MW: | 425.6 D |
| Formula: | C27H39NO3 |
Database Information
| CAS : | 469-59-0| Matching products |
| KEGG ID : | K11988 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301 |
| P Phrases: | P264, P270, P301+310, P321, P330, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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