JC2-11

JC2-11 is an inflammasome inhibitor. It inhibits increases in IL-1beta production induced by the NOD-like receptor protein 3 (NLRP3) activators ATP (Cay-14498, Cay-40182), nigericin (Cay-11437), or monosodium urate crystals in LPS-primed primary mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 50 or 100 µM. JC2-11 (100 µM) inhibits increases in IL-1beta production induced by flagellin or dsDNA, which are activators of NLR family CARD domain-containing protein 4 (NLRC4) and absent in melanoma 2 (AIM2), respectively, in LPS-primed primary mouse BMDMs. It also scavenges DPPH (Cay-14805) radicals in a cell-free assay (IC50 = 52.5 µM) and inhibits LPS-induced nitric oxide (NO) production in primary rat microglial cells. JC2-11 (10 mg/kg) inhibits LPS-induced increases in IL-1beta production in peritoneal lavage fluid in mice.Formal Name: 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-2-propen-1-one. CAS Number: 937820-89-8. Molecular Formula: C17H15FO4. Formula Weight: 302.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: COC(C=CC(C(/C=C/C1=CC(OC)=C(O)C=C1)=O)=C2)=C2F. InChi Code: InChI=1S/C17H15FO4/c1-21-16-8-5-12(10-13(16)18)14(19)6-3-11-4-7-15(20)17(9-11)22-2/h3-10,20H,1-2H3/b6-3+. InChi Key: YYAIFDXWRNNHAW-ZZXKWVIFSA-N.