IWP-3
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Larger quantity required? Request bulk
Description: IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits... more
Product information "IWP-3"
Description: IWP-3 is a potent inhibitor of Wnt production with an IC50 of 40 nM. It inhibits Porcupine (Porcn), blocking the palmitoylation of Wnt proteins, and moderately inhibits CK1gamma3 and CK1epsilon, but does not inhibit CK1alpha [1] [2]. Target: Wnt/beta-catenin. Smiles: Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccc(F)cc3)sc2c1. References: Baozhi Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb,5(2):100-7.
| Supplier: | TargetMol |
| Supplier-Nr: | T21650 |
Properties
| Application: | Porcupine inactivator |
| MW: | 484.59 D |
| Formula: | C22H17FN4O2S3 |
Database Information
| CAS : | 687561-60-0| Matching products |
| KEGG ID : | K00181 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302 |
| P Phrases: | P264, P270, P301+310, P330, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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