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Description: IWP-2 is a Wnt pathway inhibitor (IC50=27 nM) and an ATP-competitive CK1delta inhibitor (IC50=40 nM for M82FCK1delta). IWP-2 inhibits self-renewal of embryonic stem cells and has been used in stem cell and organoid research. Target: Porcupine, Casein Kinase, Wnt/beta-catenin. Smiles: Cc1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3-c3ccccc3)sc2c1. References: Chen B, et al. Nat Chem Biol, 2009, 5(2), 100-107.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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