Ivosidenib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase... more
Product information "Ivosidenib"
Description: Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells. Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH). Smiles: Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N. References: Erica Hansen, et al. Blood. 2104, 124:3734.
| Keywords: | AG-120 |
| Supplier: | TargetMol |
| Supplier-Nr: | T3617 |
Properties
| Application: | Targets isocitrate dehydrogenase [EC:1.1.1.42] (IDH1, IDH2, icd) |
| MW: | 582.96 D |
| Formula: | C28H22ClF3N6O3 |
Database Information
| CAS : | 1448347-49-6| Matching products |
| KEGG ID : | K00031 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H317, H319, H335 |
| P Phrases: | P261, P264, P271, P272, P280, P312, P321, P302+P352, P304+P340, P305+P351+P338, P332+P313, P333+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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