Ivabradine hydrochloride
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 µM).... more
Product information "Ivabradine hydrochloride"
Description: Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 µM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization. Target: Adrenergic Receptor. Smiles: N1(C(=O)Cc2c(CC1)cc(c(c2)OC)OC)CCCN(C)C[C@@H]1c2c(cc(c(c2)OC)OC)C1.Cl. References: Thollon C, et al. Br J Pharmacol, 1994,112(1):37-42.
| Keywords: | S 16257-2, Ivabradine HCl |
| Supplier: | TargetMol |
| Supplier-Nr: | T2535 |
Properties
| Application: | Cardiotonic, HCN channel blocker |
| MW: | 505.05 D |
| Formula: | C27H37ClN2O5 |
Database Information
| CAS : | 148849-67-6| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H400 |
| P Phrases: | P273, P391, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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