Ivabradine-d3 (hydrochloride)

Ivabradine-d3 is intended for use as an internal standard for the quantification of ivabradine (Cay-15868) by GC- or LC-MS. Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker that blocks the mixed sodium/potassium inward funny current (If) in HEK293 cells expressing mouse HCN1, human HCN2, and human HCN4 (EC50s = 4.5, 4.52, and 4.28 µM, respectively). In vivo, ivabradine (10 mg/kg per day) reduces heart rate, incidence of ventricular tachycardia and ventricular fibrillation, and arrhythmic mortality in a rat model of myocardial infarction. Formulations containing ivabradine have been used in the treatment of heart failure and angina.Formal Name: (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl-d3)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one, monohydrochloride. CAS Number: 1217809-61-4. Molecular Formula: C27H33D3N2O5 . HCl. Formula Weight: 508.1. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: COC(C(OC)=C1)=CC2=C1[C@H](C2)CN(C([2H])([2H])[2H])CCCN3CCC(C=C(OC)C(OC)=C4)=C4CC3=O.Cl. InChi Code: InChI=1S/C27H36N2O5.ClH/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30,/h12-14,16,21H,6-11,15,17H2,1-5H3,1H/t21-,/m1./s1/i1D3,. InChi Key: HLUKNZUABFFNQS-AFMQDYKRSA-N.