ITE

ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist. It binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays when used at a concentration of 0.01 µM. ITE (1 µM) inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells, as well as proliferation and migration of SKOV3 ovarian cancer cells. In vivo, ITE (200 µg/animal, i.p.) reduces retinal detachment and ocular inflammatory cell infiltration in a mouse model of experimental autoimmune uveitis induced by complete Freund's adjuvant (CFA) and M. tuberculosis. ITE (80 mg/kg, i.p.) reduces tumor growth by 39% in an OVCAR-3 mouse xenograft model.Formal Name: 2-(1H-indol-3-ylcarbonyl)-4-thiazolecarboxylic acid, methyl ester. CAS Number: 448906-42-1. Molecular Formula: C14H10N2O3S. Formula Weight: 286.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml, DMSO: 10 mg/ml. lambdamax: 211, 273, 279, 356 nm. SMILES: O=C(C1=NC(C(OC)=O)=CS1)C2=CNC3=CC=CC=C32. InChi Code: InChI=1S/C14H10N2O3S/c1-19-14(18)11-7-20-13(16-11)12(17)9-6-15-10-5-3-2-4-8(9)10/h2-7,15H,1H3. InChi Key: KDDXOGDIPZSCTM-UHFFFAOYSA-N.