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ITE is an endogenous aryl hydrocarbon receptor (AhR) agonist. It binds to AhR (Kd = 65 nM) and induces AhR-dependent transcription in luciferase reporter assays when used at a concentration of 0.01 µM. ITE (1 µM) inhibits anti-CD40- and IL-4-induced differentiation of isolated mouse splenic B cells, as well as proliferation and migration of SKOV3 ovarian cancer cells. In vivo, ITE (200 µg/animal, i.p.) reduces retinal detachment and ocular inflammatory cell infiltration in a mouse model of experimental autoimmune uveitis induced by complete Freund's adjuvant (CFA) and M. tuberculosis. ITE (80 mg/kg, i.p.) reduces tumor growth by 39% in an OVCAR-3 mouse xenograft model.Formal Name: 2-(1H-indol-3-ylcarbonyl)-4-thiazolecarboxylic acid, methyl ester. CAS Number: 448906-42-1. Molecular Formula: C14H10N2O3S. Formula Weight: 286.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml, DMSO: 10 mg/ml. lambdamax: 211, 273, 279, 356 nm. SMILES: O=C(C1=NC(C(OC)=O)=CS1)C2=CNC3=CC=CC=C32. InChi Code: InChI=1S/C14H10N2O3S/c1-19-14(18)11-7-20-13(16-11)12(17)9-6-15-10-5-3-2-4-8(9)10/h2-7,15H,1H3. InChi Key: KDDXOGDIPZSCTM-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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