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Isoguvacine is a GABAA receptor agonist. It binds to rat synaptic cortical membranes (Ki = 55 nM) and activates alpha1beta2gamma2S, alpha2beta2gamma2S, alpha3beta2gamma2S, alpha5beta2gamma2S, and rho1 subunit-contanining GABAA receptors in a FLIPR assay (EC50s = 13, 4.5, 5.6, 0.78, and 3.1 µM, respectively). It inhibits CA1 population spikes in rat hippocampal slices (EC50 = 13 µM) and high potassium/low magnesium-induced seizures in rat pups. Chronic administration of isoguvacine (2 mg/kg) improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of autism spectrum disorder (ASD).Formal Name: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid, monohydrochloride. CAS Number: 68547-97-7. Molecular Formula: C6H9NO2 . HCl. Formula Weight: 163.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 1 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C1=CCNCC1)O.Cl. InChi Code: InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5,/h1,7H,2-4H2,(H,8,9),1H. InChi Key: SUWREQRNTXCCBL-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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