Irinotecan-d10 (hydrochloride)

Irinotecan-d10 is intended for use as an internal standard for the quantification of irinotecan (Cay-14180) by GC- or LC-MS. Irinotecan, a derivative of the alkaloid camptothecin (Cay-11694), functions as a prodrug that is converted by tissue carboxylesterase to 7-ethyl-10-hydroxycamptothecin, a potent inhibitor of DNA topoisomerase I.{21114, 21115} Its action is terminated by glucuronidation by UDP glucuronosyl transferase 1A1.{22661, 22662} Formulations containing irinotecan demonstrate broad spectrum antitumor activity against metastatic colorectal cancer, small cell lung cancer, and several other solid tumors and have proven useful in radiation treatment of tumors by sensitizing tissue to radiation damage.{21114, 21115}Formal Name: (4S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate-2,2,3,3,4,4,5,5,6,6-d10, monohydrochloride. CAS Number: 718612-62-5. Synonyms: Camptothecin 11-d10, CPT 11- d10, Topotecin-d10, U 101440E-d10. Molecular Formula: C33H28D10N4O6 . HCl. Formula Weight: 633.2. Purity: >99% deuterated forms (d1-d10). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble, Water: soluble. SMILES: O=C(OC1=CC=C(N=C(C(N2C3)=CC([C@@](O)(CC)C(OC4)=O)=C4C2=O)C3=C5CC)C5=C1)N(CC6)CCC6N7C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C7([2H])[2H].Cl. InChi Code: InChI=1S/C33H38N4O6.ClH/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2,/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3,1H/t33-,/m0./s1/i5D2,6D2,7D2,12D2,13D2,. InChi Key: GURKHSYORGJETM-SLLIWMIESA-N.