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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay25509-500 | 500 µg | - |
6 - 10 business days* |
284.00€
|
|||
Cay25509-1 | 1 mg | - |
6 - 10 business days* |
535.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Irbesartan-d4 is intended for use as an internal standard for the quantification of irbesartan... more
Product information "Irbesartan-d4"
Irbesartan-d4 is intended for use as an internal standard for the quantification of irbesartan (Cay-11952) by GC- or LC-MS. Irbesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Ki = 1.3 nM). It is an insurmountable antagonist of AT1, as its antagonism cannot be overcome by increasing concentrations of angiotensin II. Irbesartan (3, 10, and 30 mg/kg) reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet. It also reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using apolipoprotein E (ApoE) knockout mice with diabetes induced by streptozotocin (STZ, Cay-13104). Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.Formal Name: 3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one. CAS Number: 1216883-23-6. Molecular Formula: C25H24D4N6O. Formula Weight: 432.6. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: Methanol: Heated. SMILES: CCCCC1=NC2(CCCC2)C(N1CC3=C([2H])C([2H])=C(C4=C(C5=NNN=N5)C=CC=C4)C([2H])=C3[2H])=O. InChi Code: InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30)/i11D,12D,13D,14D. InChi Key: YOSHYTLCDANDAN-WQKXEYJYSA-N.
Keywords: | 3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl-2,3,5,6-d4)methyl)-2-butyl-1,3-diazaspiro[4.4]non-1-en-4-one |
Supplier: | Cayman Chemical |
Supplier-Nr: | 25509 |
Properties
Application: | Angiotensin II receptor blocker, GC-MS, LC-MS, internal standard |
MW: | 432.6 D |
Formula: | C25H24D4N6O |
Purity: | >99% deuterated forms (d1-d4) |
Format: | Solid |
Database Information
CAS : | 1216883-23-6| Matching products |
KEGG ID : | K04166 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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