Irbesartan

Irbesartan is an orally available angiotensin II type 1 (AT1) receptor antagonist (IC50 = 1.3 nM) with antihypertensive activity. It binds to AT1 receptor with >5000 times higher affinity compared to AT2 receptor. Irbesartan also elicits selective peroxisome proliferator-activated receptor gamma (PPARgamma)-modulating activity and exhibits metabolic, anti-inflammatory and antioxidative properties. Irbesartan inhibits the receptor for advanced glycation end-products (RAGE)/high mobility group box 1 (HMGB1) axis and maybe useful in prevention and treatment of various diseases. Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.