IRAK4 Inhibitor 1

IRAK4 Inhibitor 1 (IRAK4-IN-1) is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4, IC50 = 7 nM). It reduces TNF-alpha level increases induced by the toll-like receptor 7 (TLR7) agonist resiquimod (R-848, Cay-14806) in isolated human peripheral blood mononuclear cells (PBMCs, EC50 = 300 nM).Formal Name: 4-[[trans-4-(4-morpholinyl)cyclohexyl]amino]-6-quinazolinecarbonitrile. CAS Number: 1820787-94-7. Synonyms: IRAK4-IN-1. Molecular Formula: C19H23N5O. Formula Weight: 337.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.5 mg/ml, DMSO: 10 mg/ml. lambdamax: 217 nm. SMILES: N#CC(C=C1)=CC2=C1N=CN=C2N[C@@H]3CC[C@H](CC3)N4CCOCC4. InChi Code: InChI=1S/C19H23N5O/c20-12-14-1-6-18-17(11-14)19(22-13-21-18)23-15-2-4-16(5-3-15)24-7-9-25-10-8-24/h1,6,11,13,15-16H,2-5,7-10H2,(H,21,22,23)/t15-,16-. InChi Key: HVQXFGHHSFTACS-WKILWMFISA-N.