Ipsapirone

Ipsapirone is a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 10 nM in hippocampal membranes). It reduces 5-HT release in the rat ventral hippocampus in vivo. Low doses of ipsapirone decrease, while high doses increase, extracellular dopamine release in the murine nucleus accumbens. Extracellular dopamine levels in the murine striatum increase following administration of ipsapirone at concentrations greater than 0.1 mg/kg. Ipsapirone has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively). Formulations containing ipsapirone have been used in the treatment of depression and borderline personality disorder.Formal Name: 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one, 1,1-dioxide. CAS Number: 95847-70-4. Molecular Formula: C19H23N5O3S. Formula Weight: 401.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, Methanol: Soluble. SMILES: O=S1(N(CCCCN2CCN(C3=NC=CC=N3)CC2)C(C4=C1C=CC=C4)=O)=O.Cl. InChi Code: InChI=1S/C19H23N5O3S/c25-18-16-6-1-2-7-17(16)28(26,27)24(18)11-4-3-10-22-12-14-23(15-13-22)19-20-8-5-9-21-19/h1-2,5-9H,3-4,10-15H2. InChi Key: TZJUVVIWVWFLCD-UHFFFAOYSA-N.