Iperoxo (iodide)

Iperoxo is an agonist of muscarinic acetylcholine receptors. It stimulates [35S]GTPgammaS binding to CHO cell membranes expressing human M2 muscarinic receptors and cell membranes expressing M4 muscarinic receptors (EC50s = 2.12 and 8.47 nM, respectively). Iperoxo induces M1-dependent inhibition of the twitch response in electrically-stimulated isolated rabbit vas deferens (pD2 = 9.87) and M3-mediated contraction of isolated guinea pig ileum (pD2 = 9.78). In vivo, iperoxo reduces formalin-induced paw licking and acetic acid-induced writhing in mice (ED50s = 0.004 and 0.001 mg/kg, respectively).Formal Name: 4-[(4,5-dihydro-3-isoxazolyl)oxy]-N,N,N-trimethyl-2-butyn-1-aminium, monoiodide. CAS Number: 247079-84-1. Molecular Formula: C10H17N2O2 . I. Formula Weight: 324.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 5 mg/ml (warmed). lambdamax: 225 nm. SMILES: C[N+](C)(C)CC#CCOC1=NOCC1.[I-]. InChi Code: InChI=1S/C10H17N2O2.HI/c1-12(2,3)7-4-5-8-13-10-6-9-14-11-10,/h6-9H2,1-3H3,1H/q+1,/p-1. InChi Key: XWEOIAMCTHLJJB-UHFFFAOYSA-M.