Ionomycin (calcium salt)

Ionomycin is a calcium ionophore originally isolated from S. conglobatus. It induces intracellular calcium mobilization in X. laevis oocytes when used at a concentration of 5 µM. Ionomycin (5 µM) induces the formation of neutrophil extracellular traps (NETs) in isolated human neutrophils. Ionomycin in combination with phorbol 12-myristate 13-acetate (PMA, Cay-10008014) has commonly been used to induce the proliferation and activation of T cells, as well as to stimulate cytokine production in macrophages, in vitro.Formal Name: 11,19R,21S-trihydroxy-4R,6S,8S,12R,14R,18R,20S-heptamethyl-22-[octahydro-5'S-[1R-hydroxyethyl]-2S,5'-dimethyl[2,2'R-bifuran]-5S-yl]-9-oxo-10Z,16E-docosadienoic acid, calcium salt. CAS Number: 56092-82-1. Molecular Formula: C41H70O9 . Ca. Formula Weight: 747.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1.2 mg/ml, DMSO: 1.6 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 296 nm. SMILES: C[C@@H](O)[C@](O1)(C)CC[C@]1([H])[C@]2(C)CC[C@](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)/C([O-])=C/C([C@@H](C)C[C@@H](C)C[C@H](C)CCC([O-])=O)=O)([H])O2.[Ca+2]. InChi Code: InChI=1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42,/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47),/q,+2/p-2/b13-11+. InChi Key: WKRWUYKLUMMAKG-WYGBAUISSA-L.