INF39

INF39 is an irreversible inhibitor of the NLRP3 inflammasome. INF39 (10 µM) inhibits activation of caspase-1 and the release of IL-1beta and lactate dehydrogenase (LDH) induced by ATP (Cay-14498) or nigericin (Cay-11437) in LPS-primed bone marrow-derived macrophages (BMDMs). It reduces ATP-induced pyroptosis in LPS-primed THP-1 cells by 33.6% when used at a concentration of 10 µM. INF39 (12.5, 25, and 50 mg/kg) prevents increases in IL-1beta protein levels induced by dinitrobenzene sulfonic acid (DNBS) in the colon in a rat model of colitis. It reduces the severity of pancreatic lesions and serum levels of IL-1beta, TNF-alpha, and IL-6 during caerulein- and LPS-induced pancreatitis in mice when administered at doses of 25 and 50 mg/kg.Formal Name: 2-chloro-alpha-methylene-benzenepropanoic acid, ethyl ester. CAS Number: 866028-26-4. Molecular Formula: C12H13ClO2. Formula Weight: 224.7. Purity: >98%. Formulation: (Request formulation change), An oil. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: ClC1=CC=CC=C1CC(C(OCC)=O)=C. InChi Code: InChI=1S/C12H13ClO2/c1-3-15-12(14)9(2)8-10-6-4-5-7-11(10)13/h4-7H,2-3,8H2,1H3. InChi Key: VTAOWWAFBSFWSG-UHFFFAOYSA-N.