INDY

White to off-white solid. Soluble in DMSO (10mg/ml). Potent and selective ATP-competitive DYRK1A and DYRK1B inhibitor (IC50=240nM and 230nM respectively). Binds at the ATP-binding cleft of the enzyme, Inhibits also DYRK2, DYRK3, CLK1, CLK4, casein kinase 1 (CSNK1D) and PIM1 (>90% inhibition at the same concentration), Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling, Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells, Shown to induce regeneration and expansion of rat and adult human beta-cells in vivo or ex vivo.