Indoxyl Sulfate-d5 (potassium salt)

Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate (Cay-16926) by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan (Cay-29600). It is formed via sulfation of indoxyl, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). It also inhibits the organic anion transporter (OAT) isoforms OAT1 and OAT3 (Kis = 34.2 and 74.4 µM, respectively for the rat transporters) in S2 proximal tubule cells. Indoxyl sulfate (0.2 and 1 mM) increases superoxide anion and nitric oxide levels in isolated human mononuclear blood cells. It increases serum creatinine and blood urea nitrogen (BUN) levels in the 5/6 nephrectomized rat model of chronic renal failure when administered at a dose of 50 mg/kg.Formal Name: 1H-indol-3-yl-2,4,5,6,7-d5 sulfate, potassium salt. CAS Number: 1644451-34-2. Molecular Formula: C8HD5NO4S . K. Formula Weight: 256.3. Purity: >99% deuterated forms (d1-d5). Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Methanol: slightly soluble. SMILES: [O-]S(OC1=C([2H])NC2=C([2H])C([2H])=C([2H])C([2H])=C21)(=O)=O.[K+]. InChi Code: InChI=1S/C8H7NO4S.K/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8,/h1-5,9H,(H,10,11,12),/q,+1/p-1/i1D,2D,3D,4D,5D,. InChi Key: MDAWATNFDJIBBD-GWVWGMRQSA-M.