Importazole

Importazole is a cell-permeable inhibitor of importin-beta, which transports cargo molecules bearing a nuclear localization signal into the nucleus. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells (IC50 = 15 µM), which is reversible upon importazole washout. Importazole does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export. Importazole inhibits nuclear import of topoisomerase IIbeta binding protein 1 (TopBP1) in Xenopus egg extracts and of NF-kappaB in multiple myeloma cells. It also induces defects in spindle and microtubule formation in vitro.Formal Name: N-(1-phenylethyl)-2-(1-pyrrolidinyl)-4-quinazolinamine. CAS Number: 662163-81-7. Synonyms: IPZ. Molecular Formula: C20H22N4. Formula Weight: 318.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml, Ethanol: 5 mg/ml. lambdamax: 242, 338 nm. SMILES: [H]N(C(C1=CC=CC=C1)C)C2=NC(N3CCCC3)=NC4=C2C=CC=C4. InChi Code: InChI=1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23). InChi Key: HKGJEZIGDHFJFL-UHFFFAOYSA-N.