Imetit (hydrobromide)

Imetit is a histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H3 and H4 receptors over H1 and H2 receptors at concentrations up to 100 µM, as well as the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 240 nM). Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 = 2.8 nM). It increases scratching in mice (ED50 = 0.9 µmol), an effect that is reduced by the H3 receptor antagonist thioperamide (Cay-10011127).Formal Name: carbamimidothioic acid, 2-(1H-imidazol-5-yl)ethyl ester, dihydrobromide. CAS Number: 32385-58-3. Synonyms: VUF 8325. Molecular Formula: C6H10N4S . 2HBr. Formula Weight: 332.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Water: 100 mM. SMILES: NC(SCCC1=CN=CN1)=N.Br.Br. InChi Code: InChI=1S/C6H10N4S.2BrH/c7-6(8)11-2-1-5-3-9-4-10-5,,/h3-4H,1-2H2,(H3,7,8)(H,9,10),2*1H. InChi Key: DOBOYMKCRRLTRF-UHFFFAOYSA-N.