IKK2 Inhibitor VI

Inhibitor of NF-kappaB kinase 2 (IKK2, also known as IKKbeta) acts as part of an IKK complex in the canonical NF-kappaB pathway, phosphorylating inhibitors of NF-kappaB (IkappaBs) to initiate signaling. NF-kappaB signaling can also occur through a non-canonical, IKK/IkappaB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). It is used to evaluate the role of the canonical, IkappaB-dependent NF-kappaB signaling pathway in cellular responses.Formal Name: 2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide. CAS Number: 354811-10-2. Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide. Molecular Formula: C12H11N3O2S. Formula Weight: 261.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 2 mg/ml. lambdamax: 212, 233, 314 nm. SMILES: O=C(N)NC1=C(C(N)=O)C=C(C2=CC=CC=C2)S1. InChi Code: InChI=1S/C12H11N3O2S/c13-10(16)8-6-9(7-4-2-1-3-5-7)18-11(8)15-12(14)17/h1-6H,(H2,13,16)(H3,14,15,17). InChi Key: PSVUSJKZJQMCSP-UHFFFAOYSA-N.