IHCH-7079

IHCH-7079 is a beta-arrestin-biased agonist of the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 16.98 nM). It reduces the time spent immobile in the tail suspension and forced swim tests in mice in a model of acute restraint stress-induced depression when administered at a dose of 10 mg/kg, and this effect can be blocked by the 5-HT2A receptor antagonist MDL100907 (volinanserin, Cay-15936). IHCH-7079 (2 and 10 mg/kg) does not induce the head-twitch response in mice, indicating a lack of hallucinogenic potential.Formal Name: 2,3,6bR,7,8,9,10,10aS-octahydro-8-[2-(2-methoxyphenyl)ethyl]-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline. CAS Number: 2957888-63-8. Molecular Formula: C23H29N3O. Formula Weight: 363.5. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: soluble. SMILES: CN1C2=C3N(CC1)[C@](CCN4CCC(C=CC=C5)=C5OC)([H])[C@](C4)([H])C3=CC=C2. InChi Code: InChI=1S/C23H29N3O/c1-24-14-15-26-20-11-13-25(12-10-17-6-3-4-9-22(17)27-2)16-19(20)18-7-5-8-21(24)23(18)26/h3-9,19-20H,10-16H2,1-2H3/t19-,20-/m0/s1. InChi Key: FCGZRBNMPIAEDK-PMACEKPBSA-N.