iFSP1

iFSP1 is an inhibitor of apoptosis inducing factor mitochondria-associated 2/ferroptosis suppressor protein 1 (AIFM2/FSP1). It decreases cell viability in wild-type, but not glutathione peroxidase 4 (GPX4) knock-out, Pfa1 and HT1080 cells overexpressing AIFM2/FSP1, an effect that can be blocked by the ferroptosis inhibitor liproxstatin-1 (Cay-17730). iFSP1 (3 µM) sensitizes a variety of human cancer cell lines to the ferroptosis inducer (1S,3R)-RSL3 (Cay-19288).Formal Name: 1-amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile. CAS Number: 150651-39-1. Molecular Formula: C20H13N5. Formula Weight: 323.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:7): 0.1 mg/ml, DMSO: 25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 248, 283 nm. SMILES: NC1=C(C#N)C(C2=CC=C(C)C=C2)=C(C#N)C3=NC4=CC=CC=C4N31. InChi Code: InChI=1S/C20H13N5/c1-12-6-8-13(9-7-12)18-14(10-21)19(23)25-17-5-3-2-4-16(17)24-20(25)15(18)11-22/h2-9H,23H2,1H3. InChi Key: FNESYDFRCQEEKA-UHFFFAOYSA-N.