IDO-IN-2

IDO-IN-2 is an inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1, IC50 = 0.097 µM in HeLa cells). In vivo, IDO-IN-2 (100 mg/kg) decreases intratumor levels of Ki67, a marker of cell proliferation, and reduces tumor weight in a GL261 murine glioma heterotopic transplantation model. It also decreases mechanical and thermal hypersensitivity, improves novel object recognition, and decreases anterior cingulate cortex (ACC) and amygdala levels of IDO1 in a rat model of neuropathic pain induced by spinal nerve ligation (SNL).Formal Name: N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)-urea. CAS Number: 1668565-74-9. Synonyms: PCC0208009. Molecular Formula: C29H35N7O. Formula Weight: 497.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): insol. lambdamax: 257 nm. SMILES: O=C(NC1=C(N(CC(C)C)CC(C)C)C=CC(C2=C(C3=NN=NN3)C=CC=C2)=C1)NC4=CC=C(C)C=C4. InChi Code: InChI=1S/C29H35N7O/c1-19(2)17-36(18-20(3)4)27-15-12-22(24-8-6-7-9-25(24)28-32-34-35-33-28)16-26(27)31-29(37)30-23-13-10-21(5)11-14-23/h6-16,19-20H,17-18H2,1-5H3,(H2,30,31,37)(H,32,33,34,35). InChi Key: CJNMMPAEIYFQIJ-UHFFFAOYSA-N.