ICA 121431

ICA 121431
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay24669-1 1 mg -

6 - 10 business days*

43.00€
Cay24669-5 5 mg -

6 - 10 business days*

146.00€
Cay24669-10 10 mg -

6 - 10 business days*

267.00€
Cay24669-25 25 mg -

6 - 10 business days*

563.00€
 
ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and... more
Product information "ICA 121431"
ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = 10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 µM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold.Formal Name: alpha-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide. CAS Number: 313254-51-2. Molecular Formula: C23H19N3O3S2. Formula Weight: 449.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 15 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml, Ethanol: 0.1 mg/ml. lambdamax: 205, 260, 287 nm. SMILES: O=C(NC1=CC=C(S(NC2=NC=CS2)(=O)=O)C=C1)C(C3=CC=CC=C3)C4=CC=CC=C4. InChi Code: InChI=1S/C23H19N3O3S2/c27-22(21(17-7-3-1-4-8-17)18-9-5-2-6-10-18)25-19-11-13-20(14-12-19)31(28,29)26-23-24-15-16-30-23/h1-16,21H,(H,24,26)(H,25,27). InChi Key: URSQNPPONHUJDL-UHFFFAOYSA-N.
Keywords: alpha-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide
Supplier: Cayman Chemical
Supplier-Nr: 24669

Properties

Application: Voltage-gated sodium channel (Nav) blocker
MW: 449.5 D
Formula: C23H19N3O3S2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 313254-51-2| Matching products
KEGG ID : K04836 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302, H319, H413
P Phrases: P264, P270, P273, P280, P301+310, P305+351+338, P330, P337+313, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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