IC87201

IC87201 is an inhibitor of the protein-protein interaction between neuronal nitric oxide synthase (nNOS) and post-synaptic density protein 95 (PSD-95). It inhibits the binding of PSD-95 to nNOS (IC50 = 31 µM). IC87201 inhibits NMDA-induced cGMP production, a marker of PSD-95-dependent NOS activation, in primary rat hippocampal neurons (IC50 = 2.7 µM). IC87201 (10 µM) reduces MPP+-induced production of reactive oxygen species (ROS), cytochrome c release, and apoptosis in primary rat cortical neurons. In vivo, IC87201 decreases thermal hyperalgesia in mice (ED50 = 0.1 mg/kg), as well as mechanical allodynia in a rat model of neuropathic pain induced by chronic constriction injury (CCI). It also reduces immobility time in the forced swim and tail suspension tests in mice when administered at a dose of 1 mg/kg.Formal Name: 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-phenol. CAS Number: 866927-10-8. Molecular Formula: C13H10Cl2N4O. Formula Weight: 309.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml, Ethanol: 1 mg/ml. lambdamax: 228 nm. SMILES: ClC1=CC(CNC2=CC3=C(N=NN3)C=C2)=C(O)C(Cl)=C1. InChi Code: InChI=1S/C13H10Cl2N4O/c14-8-3-7(13(20)10(15)4-8)6-16-9-1-2-11-12(5-9)18-19-17-11/h1-5,16,20H,6H2,(H,17,18,19). InChi Key: QEHVTUCLCBXQIC-UHFFFAOYSA-N.