Ibrutinib
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that... more
Product information "Ibrutinib"
Description: Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation. Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC. Smiles: NC1=C2C(N(N=C2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(C=C)=O)CCC5)=NC=N1. References: Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20,107(29):13075-80.
| Keywords: | PCI-32765 |
| Supplier: | TargetMol |
| Supplier-Nr: | T1835 |
Properties
| Application: | Targets Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2] (BTK) |
| MW: | 440.5 D |
| Formula: | C25H24N6O2 |
Database Information
| CAS : | 936563-96-1| Matching products |
| KEGG ID : | K07370 | Matching products |
| Protein Atlas Nr. : | Tyrosine Phosphorylation |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335, H360 |
| P Phrases: | P201, P202, P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P308+P313, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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