Hypoxanthine

Hypoxanthine is an endogenous purine derivative and the major purine involved in the purine salvage pathway in the brain. Intrastriatal administration of hypoxanthine (10 µM) increases mitochondrial complex II, also known as succinate dehydrogenase, activity and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rats. Hypoxanthine also induces hyperuricemia in mice. Spinal fluid levels of hypoxanthine are increased in patients with Lesh-Nyhan syndrome, an inborn error of metabolism characterized by cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia.Formal Name: 1,9-dihydro-6H-purin-6-one. CAS Number: 68-94-0. Synonyms: 6-Hydroxypurine, NSC 14665, NSC 129419. Molecular Formula: C5H4N4O. Formula Weight: 136.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/mL, DMSO: 30 mg/mL, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL, Ethanol: 0.5 mg/mL. lambdamax: 251 nm. SMILES: O=C1NC=NC2=C1NC=N2. InChi Code: InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10). InChi Key: FDGQSTZJBFJUBT-UHFFFAOYSA-N.