Hygromycin A

Hygromycin A is an antibiotic originally isolated from S. hygroscopicus. It is active against numerous spirochete bacteria, including T. pallidum, L. biflexa, and four strains of B. burgdorferi (MICs = 0.03-4 µg/ml for all). Hygromycin A binds to the peptidyl transferase center (PTC) in the 70S ribosomal subunit to inhibit protein synthesis. It completely eliminates bacterial infection in skin biopsies from B. burgdorferi-infected mice in a model of acute Lyme disease when administered at doses ranging from 50 to 250 mg/kg twice per day.Formal Name: 5-deoxy-5-[[(2E)-3-[4-[(6-deoxy-beta-D-arabino-hexofuranos-5-ulos-1-yl)oxy]-3-hydroxyphenyl]-2-methyl-1-oxo-2-propen-1-yl]amino]-1,2-O-methylene-D-neo-inositol. CAS Number: 6379-56-2. Synonyms: (-)-Hygromycin A, Totomycin. Molecular Formula: C23H29NO12. Formula Weight: 511.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15 mg/mL, DMSO: 10 mg/mL, Ethanol: 12 mg/mL, PBS (pH 7.2): 10 mg/mL. lambdamax: 218, 274 nm. SMILES: O[C@H]1[C@@]2([H])[C@@](OCO2)([H])[C@@H]([C@H]([C@H]1NC(/C(C)=C/C3=CC(O)=C(C=C3)O[C@H]4[C@@H](O)[C@H](O)[C@@H](C(C)=O)O4)=O)O)O. InChi Code: InChI=1S/C23H29NO12/c1-8(22(32)24-13-14(27)16(29)21-20(15(13)28)33-7-34-21)5-10-3-4-12(11(26)6-10)35-23-18(31)17(30)19(36-23)9(2)25/h3-6,13-21,23,26-31H,7H2,1-2H3,(H,24,32)/b8-5+/t13-,14+,15-,16-,17+,18+,19-,20+,21-,23-/m1/s1. InChi Key: YQYJSBFKSSDGFO-IIHALWDASA-N. Origin: Bacterium/Streptomyces hygro.