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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay22375-500 | 500 µg | - |
6 - 10 business days* |
294.00€
|
|||
Cay22375-1 | 1 mg | - |
6 - 10 business days* |
525.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Hydroxychloroquine-d4 (sulfate) is intended for use as an internal standard for the... more
Product information "Hydroxychloroquine-d4 (sulfate)"
Hydroxychloroquine-d4 (sulfate) is intended for use as an internal standard for the quantification of hydroxychloroquine (Cay-17911) by GC- or LC-MS. Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities. It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM). Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) and ionomycin (Cay-10004974) in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner. Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques. Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.Formal Name: 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-ethanol-1,1,2,2-d4, monosulfate. CAS Number: 1854126-45-6. Synonyms: HCQ-d4. Molecular Formula: C18H22D4ClN3O . H2SO4. Formula Weight: 438.0. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solution in ethanol. Solubility: Water: 100 mM. SMILES: CC(CCCN(CC)C([2H])([2H])C([2H])([2H])O)NC1=CC=NC2=CC(Cl)=CC=C21.O=S(O)(O)=O. InChi Code: InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18,1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21),(H2,1,2,3,4)/i11D2,12D2,. InChi Key: JCBIVZZPXRZKTI-ZYMFQSNRSA-N.
Keywords: | HCQ-d4, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-ethanol-1,1,2,2-d4, monosulfate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 22375 |
Properties
Application: | GC-MS, LC-MS, internal standard, antimalarial, lupus erythematosus suppressant |
MW: | 438 D |
Formula: | C18H22D4ClN3O . H2SO4 |
Purity: | >99% deuterated forms (d1-d4) |
Format: | Solid |
Database Information
CAS : | 1854126-45-6| Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H225, H319, H333 |
P Phrases: | P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P304+312, P305+351+338, P337+313, P370+378, P403+235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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