Hydroflumethiazide

Hydroflumethiazide is a thiazide diuretic that also inhibits carbonic anhydrase (CA). It is selective for CAII, VB, VII, IX, XII, and XIV (Kis = 305-235 nM) over CAI, IV, and VI (Kis = 2,840-8,250 nM) and CAIII, VA, and XIII (Kis = >10 µM). Diuretics of the thiazide class, of which hydroflumethiazide is a member, inhibit the renal Na+/Cl- cotransporter. Formulations containing hydroflumethiazide have been used as diuretics.Formal Name: 3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide, 1,1-dioxide. CAS Number: 135-09-1. Synonyms: NSC 44627. Molecular Formula: C8H8F3N3O4S2. Formula Weight: 331.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly Soluble, Methanol: Slightly Soluble. SMILES: O=S1(C2=C(C=C(C(F)(F)F)C(S(N)(=O)=O)=C2)NCN1)=O. InChi Code: InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16). InChi Key: DMDGGSIALPNSEE-UHFFFAOYSA-N.