Hydrochlorothiazide Impurity C

Description: Hydrochlorothiazide impurity C is a potential impurity found in commercial hydrochlorothiazide preparations. [1] Hydrochlorothiazide is a thiazide diuretic that inhibits the apical membrane sodium chloride cotransporter in the distal and collecting duct nephron segments.[2][3][4]. Target: Others. Smiles: O=S(=O)(N)C=1C=C2C(=CC1Cl)N(CNS(=O)(=O)C=3C=C4C(=CC3Cl)NCNS4(=O)=O)CNS2(=O)=O. References: Fang, X., Bibart, R.T., Mayr, S., et al. Purification and identification of an impurity in bulk hydrochlorothiazide. J. Pharm. Sci. 90(11), 1800-1809 (2001).