HX 531

HX 531 is an antagonist of the retinoid X receptor (RXR) with an IC50 value of 18 nM that inhibits 9-cis retinoic acid (Cay-14587)-induced transactivation of RXR. It has been shown to reduce triglyceride content in white adipose tissue, skeletal muscle, and the liver of mice on a high fat diet.Formal Name: 4-(7,8,9,10-tetrahydro-5,7,7,10,10-pentamethyl-2-nitro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)-benzoic acid. CAS Number: 188844-34-0. Molecular Formula: C29H29N3O4. Formula Weight: 483.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.12 mg/ml. lambdamax: 264 nm. SMILES: CC1(C)C2=C(C=C(N(C)C(C=CC([N+]([O-])=O)=C3)=C3N=C4C5=CC=C(C(O)=O)C=C5)C4=C2)C(C)(C)CC1. InChi Code: InChI=1S/C29H29N3O4/c1-28(2)12-13-29(3,4)22-16-25-20(15-21(22)28)26(17-6-8-18(9-7-17)27(33)34)30-23-14-19(32(35)36)10-11-24(23)31(25)5/h6-11,14-16H,12-13H2,1-5H3,(H,33,34). InChi Key: SXKPGYKPQPYJER-UHFFFAOYSA-N.