HT-2 Toxin-13C22

HT-2 toxin-13C22 is intended for use as an internal standard for the quantification of HT-2 toxin (Cay-20431) by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin (Cay-11444). Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants. HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50 values ranging from 3.1 to 23 ng/ml and human umbilical vein endothelial cells with an IC50 value of 56.4 ng/ml. It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM. HT-2 toxin has been found in cereal grains and food products.Formal Name: (2S,2'R,3'R,4'S,5'S,5a'R,7'S,9a'R)-5a'-((acetoxy-13C2)methyl-13C)-3',4'-dihydroxy-5',8'-di(methyl-13C)-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-7'-yl-2,2',3,3',4',5',5a',6',7',8',9',9a'-13C12 3-(methyl-13C)butanoate-1,2,3,4-13C4. CAS Number: 1486469-92-4. Molecular Formula: [13C]22H32O8. Formula Weight: 446.3. Purity: >98%. Formulation: (Request formulation change), A 25 µg/ml solution in acetonitrile. Solubility: Acetonitrile: soluble. SMILES: [13CH3][13C]1=[13CH][13C@]2([H])[13C@]([13C@]([13C@H](O)[13C@H]3O)([13CH3])[13C@]4([13CH2]O4)[13C@]3([H])O2)([13CH2]O[13C]([13CH3])=O)[13CH2][13C@@H]1O[13C]([13CH2][13CH]([13CH3])[13CH3])=O. InChi Code: InChI=1S/C22H32O8/c1-11(2)6-16(24)29-14-8-21(9-27-13(4)23)15(7-12(14)3)30-19-17(25)18(26)20(21,5)22(19)10-28-22/h7,11,14-15,17-19,25-26H,6,8-10H2,1-5H3/t14-,15+,17+,18+,19+,20+,21+,22-/m0/s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1,11+1,12+1,13+1,14+1,15+1,16+1,17+1,18+1,19+1,20+1,21+1,22+1. InChi Key: PNKLMTPXERFKEN-YSKZOFMMSA-N.