HS-1371

HS-1371 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 20.8 nM). It inhibits basal RIPK3 autophosphorylation and TNF-alpha- or TRAIL-induced necroptosis in HT-29 cells when used at a concentration of 5 µM. It also inhibits necroptosis induced by a TNF-alpha Smac mimetic and the caspase inhibitor Z-VAD in HeLa cervical and NCI-H2009 lung cancer cells ectopically expressing RIPK3.Formal Name: 4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-quinoline. CAS Number: 2158197-70-5. Molecular Formula: C24H24N4O. Formula Weight: 384.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 5 mg/ml, Ethanol: 5 mg/ml. lambdamax: 267 nm. SMILES: CC1=CC=C(C=C1)OC2=CC=NC3=C2C=CC(C4=CN(C5CCNCC5)N=C4)=C3. InChi Code: InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3. InChi Key: VPVLPCIBKVWFDT-UHFFFAOYSA-N.