HLCL-61 (hydrochloride)

HLCL-61 is an inhibitor of protein arginine methyltransferase 5 (PRMT5) that inhibits the growth of multiple acute myeloid leukemia (AML) cell lines and patient-derived tumor samples (IC50s = 7.21-21.46 and 3.98-8.72 µM, respectively). It is selective for PRMT5, lacking activity against PRMT1, PRMT4, and PRMT7 in an enzyme assay. HLCL-61 induces myeloid differentiation of THP-1 cells and increases CD11b expression in a dose-dependent manner. It also increases expression of miR-29b mRNA resulting in a 4-fold decrease in FLT3 activity in THP-1 cells expressing an FLT3 luciferase reporter.Formal Name: 9-ethyl-N-[(2-methoxyphenyl)methyl]-9H-carbazole-3-methanamine, monohydrochloride. CAS Number: 1158279-20-9. Molecular Formula: C23H24N2O . HCl. Formula Weight: 380.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: >1mg/ml, Ethanol: >1mg/ml. lambdamax: 239, 267, 297 nm. SMILES: COC1=CC=CC=C1CNCC2=CC=C(N(CC)C3=C4C=CC=C3)C4=C2.Cl. InChi Code: InChI=1S/C23H24N2O.ClH/c1-3-25-21-10-6-5-9-19(21)20-14-17(12-13-22(20)25)15-24-16-18-8-4-7-11-23(18)26-2,/h4-14,24H,3,15-16H2,1-2H3,1H. InChi Key: XYAVCNMZZKTEGR-UHFFFAOYSA-N.