HIV-1 Integrase Inhibitor 1

HIV-1 integrase inhibitor 1 is an inhibitor of HIV-1 integrase DNA strand transfer (IC50 = 14 nM). It is also an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), also known as 3C-like protease (3CLpro), when used at a concentration of 10 µM in a fluorescence-based assay. HIV-1 integrase inhibitor 1 decreases SARS-CoV-2 replication (EC50 = 0.27 µM) and reduces particle-forming units (PFUs) in infected Huh7.5 cells in a concentration-dependent manner.Formal Name: N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-(tetrahydro-1,1-dioxido-2H-1,2-thiazin-2-yl)-4-pyrimidinecarboxamide. CAS Number: 729607-74-3. Synonyms: BMS-707035. Molecular Formula: C17H19FN4O5S. Formula Weight: 410.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble. lambdamax: 253, 302 nm. SMILES: O=C(C(N=C(N1CCCCS1(=O)=O)N2C)=C(O)C2=O)NCC3=CC=C(C=C3)F. InChi Code: InChI=1S/C17H19FN4O5S/c1-21-16(25)14(23)13(15(24)19-10-11-4-6-12(18)7-5-11)20-17(21)22-8-2-3-9-28(22,26)27/h4-7,23H,2-3,8-10H2,1H3,(H,19,24). InChi Key: VNIWZCGZPBJWBI-UHFFFAOYSA-N.