Hexa-D-Arginine (trifluoroacetate salt)

Hexa-D-arginine is an inhibitor of the proprotein convertase furin (Ki = 100 nM). It also inhibits West Nile virus nonstructural protein 3 (NS3) protease (Ki = 478 nM). Hexa-D-arginine (1 µg/ml) reduces the proliferation, invasion, and migration of SW 1990 and PaTu 8988 pancreatic cancer cells, as well as decreases the levels of N-cadherin and vimentin and increases E-cadherin levels, markers of the epithelial-to-mesenchymal transition (EMT), in the same cells. It improves survival in a rat model of anthrax toxemia induced by the anthrax toxins protective antigen and lethal factor.Formal Name: D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-arginyl-D-argininamide, trifluoroacetate salt. Synonyms: Furin Inhibitor II, Hexa-D-Arg-NH2, Hexa-D-Arginine amide, D6R-NH2, (D)RRRRRR-NH2. Molecular Formula: C36H75N25O6 . XCF3COOH. Formula Weight: 954.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile/H2O (80:20): 1 mg/ml. SMILES: N=C(N)NCCC[C@@H](N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@H](CCCNC(N)=N)C(N[C@@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O. InChi Code: InChI=1S/C36H75N25O6.C2HF3O2/c37-19(7-1-13-51-31(39)40)26(63)58-21(9-3-15-53-33(43)44)28(65)60-23(11-5-17-55-35(47)48)30(67)61-24(12-6-18-56-36(49)50)29(66)59-22(10-4-16-54-34(45)46)27(64)57-20(25(38)62)8-2-14-52-32(41)42,3-2(4,5)1(6)7/h19-24H,1-18,37H2,(H2,38,62)(H,57,64)(H,58,63)(H,59,66)(H,60,65)(H,61,67)(H4,39,40,51)(H4,41,42,52)(H4,43,44,53)(H4,45,46,54)(H4,47,48,55)(H4,49,50,56),(H,6,7)/t19-,20-,21-,22-,23-,24-,/m1./s1. InChi Key: PWFVPQZWAYQQHX-MZYAMQFBSA-N.