Herkinorin

Description: Herkinorin is an opioid analgesic and an analogue of the natural product Salvinorin A. herkinorin is a µ-opioid agonist with more than 100x higher µ-opioid affinity and 50x lower kappa-opioid affinity compared to Salvinorin A. Herkinorin is a semi-synthetic compound, made from Salvinorin B, which is most conveniently made from Salvinorin A by deacetylation, as while both Salvinorin A and Salvinorin B are found in the plant Salvia divinorum, Salvinorin A is present in larger quantities. Target: Others. Smiles: C[C@@]12[C@@]3([C@](C)([C@H](C(OC)=O)C[C@H](OC(=O)C4=CC=CC=C4)C3=O)CC[C@]1(C(=O)O[C@@H](C2)C=5C=COC5)[H])[H]. References: Butelman ER, Rus S, Simpson DS, Wolf A, Prisinzano TE, Kreek MJ. The effects of herkinorin, the first mu-selective ligand from a salvinorin A-derived scaffold, in a neuroendocrine biomarker assay in nonhuman primates. J Pharmacol Exp Ther. 2008 Oct,327(1):154-60. doi: 10.1124/jpet.108.140079. Epub 2008 Jul 1. PubMed PMID: 18593955, PubMed Central PMCID: PMC2614932.