Heliquinomycin

Heliquinomycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities. It is active against a variety of Gram-positive bacteria, including strains of B. anthracis, B. subtilis, and methicillin-sensitive or -resistant S. aureus (MICs = i value of 6.8 µM. It reduces the growth of L1210 leukemia, B16 melanoma, and FS-3 fibrosarcoma cells (IC50s = 0.97, 0.89, and 0.83 µg/ml, respectively).Formal Name: (2R,3R,3'R)-3'-[(2,6-dideoxy-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-4,5',8',9-tetrahydro-3,4',9',10-tetrahydroxy-7'-methoxy-5',8',9-trioxo-spiro[benzo[1,2-b:5,4-c']dipyran-2(3H),2'(3'H)-naphtho[2,3-b]furan]-7-carboxylic acid, methyl ester. CAS Number: 178182-49-5. Synonyms: NSC 702208, Rubymycin. Molecular Formula: C33H30O17. Formula Weight: 698.6. Purity: >80%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: O[C@@H]1CC2=CC3=C(C(OC(C(OC)=O)=C3)=O)C(O)=C2O[C@@]14OC5=C(O)C(C(C(OC)=CC6=O)=O)=C6C(O)=C5[C@H]4O[C@H]7C[C@@H](OC)[C@@H](O)[C@H](C)O7. InChi Code: InChI=1S/C33H30O17/c1-10-23(36)15(44-3)9-18(46-10)48-30-22-25(38)20-13(34)8-14(43-2)24(37)21(20)27(40)29(22)50-33(30)17(35)7-12-5-11-6-16(31(41)45-4)47-32(42)19(11)26(39)28(12)49-33/h5-6,8,10,15,17-18,23,30,35-36,38-40H,7,9H2,1-4H3/t10-,15+,17+,18-,23-,30+,33+/m0/s1. InChi Key: MLFZQFHGXSVTGX-MCTZXALVSA-N. Origin: Bacterium/Streptomyces sp..