Hedgehog Antagonist VIII

Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity with an IC50 value of 70 nM.Formal Name: N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[[3-(4-fluorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]-urea. CAS Number: 330796-24-2. Synonyms: Hh Antagonist VIII. Molecular Formula: C23H15ClF4N4O2. Formula Weight: 490.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml. lambdamax: 225, 253 nm. SMILES: O=C1C2=CC=CC=C2N=C(CNC(NC3=CC=C(Cl)C(C(F)(F)F)=C3)=O)N1C4=CC=C(F)C=C4. InChi Code: InChI=1S/C23H15ClF4N4O2/c24-18-10-7-14(11-17(18)23(26,27)28)30-22(34)29-12-20-31-19-4-2-1-3-16(19)21(33)32(20)15-8-5-13(25)6-9-15/h1-11H,12H2,(H2,29,30,34). InChi Key: NYOXUHUPXGFHIB-UHFFFAOYSA-N.