HDMAPP (ammonium salt)

HDMAPP is a metabolite of the microbial dioxyxylulose-phosphate pathway, which is analogous to the isopentenyl pyrophosphate pathway in mammals. It is a protease-resistant and phosphatase-sensitive pyrophosphate produced by bacteria and plants. HDMAPP is a non-peptide ligand, also called a phosphoantigen, that binds the T cell receptor on Vgamma9Vdelta2 peripheral blood lymphocytes with high affinity (EC50 = 0.39 nM). It induces the expansion of human memory Vgamma9Vdelta2 T cells, but does not increase their ability to inhibit intracellular mycobacterial growth. Neonatal Vgamma9Vdelta2 T cells require micromolar concentrations of HDMAPP to drive expansion.Formal Name: diphosphoric acid, mono[(2E)-4-hydroxy-3-methyl-2-butenyl] ester, triammonium salt. CAS Number: 443892-56-6. Synonyms: HMBPP. Molecular Formula: C5H9O8P2 . 3NH4. Formula Weight: 313.2. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: [O-]P(OP([O-])(OC/C=C(CO)\C)=O)([O-])=O.[NH4+].[NH4+].[NH4+]. InChi Code: InChI=1S/C5H12O8P2.3H3N/c1-5(4-6)2-3-12-15(10,11)13-14(7,8)9,,,/h2,6H,3-4H2,1H3,(H,10,11)(H2,7,8,9),3*1H3/b5-2+,,,. InChi Key: YPBALCNFFTVQJJ-JZWSQSCTSA-N.